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The annotation and conditions in this rule are derived from the following entries: P06968 (DUT_ECOLI), P9WNS5 (DUT_MYCTU)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00116
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 87 - 89 does not align to "[TVL]-[IV]-D" in entry P06968
    • Subsequence at position 89 - 89 aligns to "D" in entry P06968
    • Subsequence at position 87 - 89 aligns to "[TVL]-[IV]-D" in entry P06968
    • Subsequence at position 70 - 72 aligns to "R-S-[GS]" in entry P06968 (individually applies "Substrate binding")
    • Subsequence at position 83 - 83 aligns to "[NQ]" in entry P06968 (individually applies "Substrate")
    • Subsequence at position 97 - 97 aligns to "[KM]" in entry P06968 (individually applies "Substrate; via amide nitrogen and carbonyl oxygen")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase

Gene namei

  • Name:dut

Cofactori

Subunit structurei

  • Homotrimer.

Catalytic activityi

  • dUTP + H2O = dUMP + diphosphate.

Pathwayi

  • Pathwayi: dUMP biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route). This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sequence similaritiesi

Functioni

  • This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Binding sitei

  • Substrate (to residues corresponding to position 89)
  • Substrate (to residues corresponding to position 83)
  • Substrate; via amide nitrogen and carbonyl oxygen (to residues corresponding to position 97)

Regioni

  • Substrate binding (to residues corresponding to positions 87 - 89)
  • Substrate binding (to residues corresponding to positions 70 - 72)

Keywordsi

GO (Gene Ontology) termsi

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