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The annotation and conditions in this rule are derived from the following entries: P29597 (TYK2_HUMAN), Q62120 (JAK2_MOUSE), Q62137 (JAK3_MOUSE), P52333 (JAK3_HUMAN), P23458 (JAK1_HUMAN), O60674 (JAK2_HUMAN)

If a protein meets these conditions... i

Common conditions

    • Matches PIR Superfamily signature PIRSF000636
    • sequence length = 1081 - 1207
    • taxon = Vertebrata
    • fragment ≠ the sequence is fragmented

... then these annotations are applied i

Protein namei

  • Recommended name:
    Tyrosine-protein kinase (EC:

Sequence similaritiesi

Catalytic activityi

  • ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.


GO (Gene Ontology) termsi