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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 22 - 26 aligns to "L-x-C-x-E" in entry P03129 (individually applies "LXCXE motif; interaction with host RB1 and TMEM173/STING")
    • Subsequence at position 58 - 94 aligns to "C-x*-C-x-x-C" in entry P03129 (individually applies "")
    • Subsequence at position 76 - 84 aligns to entry P03129 (individually applies "Nuclear export signal")
    • Subsequence at position @NTER@ - 40 aligns to entry P03129 (individually applies "Disordered")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Protein E7

Gene namei

  • Name:E7

Subunit structurei

  • Homodimer. Homooligomer. Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity. Interacts with host EP300; this interaction represses EP300 transcriptional activity. Interacts with protein E2; this interaction inhibits E7 oncogenic activity. Interacts with host TMEM173/STING; this interaction impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).

Sequence similaritiesi

Post-translational modificationi

  • Highly phosphorylated.

Functioni

  • Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).

Subcellular locationi

Motifi

  • LXCXE motif; interaction with host RB1 and TMEM173/STING (to residues corresponding to positions 22 - 26)
  • Nuclear export signal (to residues corresponding to positions 76 - 84)

Regioni

  • Disordered (to residues corresponding to positions @NTER@i - 40)

Zinc fingeri

  • (to residues corresponding to positions 58 - 94)

Keywordsi

GO (Gene Ontology) termsi