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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_03168
    • taxon = Eukaryota
    • fragment ≠ the sequence is fragmented

Special conditions

    • taxon = Vertebrata Subsequence at position 42 - 92 aligns to "C-x*-C" in entry P54819
    • taxon = Mammalia
    • Subsequence at position 1 - 1 aligns to "M" in entry P54819
    • Subsequence at position 16 - 21 aligns to "G-[AS]-G-K-G-T" in entry P07170 (individually applies "ATP")
    • Subsequence at position 36 - 65 aligns to entry P07170 (individually applies "NMPbind")
    • Subsequence at position 37 - 37 aligns to "T" in entry P07170 (individually applies "AMP")
    • Subsequence at position 42 - 42 aligns to "R" in entry P07170 (individually applies "AMP")
    • Subsequence at position 63 - 65 aligns to "x-L-V" in entry P07170 (individually applies "AMP")
    • Subsequence at position 92 - 95 aligns to "G-F-P-R" in entry P07170 (individually applies "AMP")
    • Subsequence at position 99 - 99 aligns to "Q" in entry P07170 (individually applies "AMP")
    • Subsequence at position 133 - 170 aligns to entry P07170 (individually applies "LID")
    • Subsequence at position 134 - 134 aligns to "R" in entry P07170 (individually applies "ATP")
    • Subsequence at position 143 - 144 aligns to "[ST]-Y" in entry P07170 (individually applies "ATP")
    • Subsequence at position 167 - 167 aligns to "R" in entry P07170 (individually applies "AMP")
    • Subsequence at position 178 - 178 aligns to "R" in entry P07170 (individually applies "AMP")
    • Subsequence at position 206 - 206 aligns to entry P07170 (individually applies "ATP; via carbonyl oxygen")
    • taxon = Vertebrata
    • Subsequence at position 42 - 92 aligns to "C-x*-C" in entry P54819

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Adenylate kinase 2, mitochondrial (EC:2.7.4.3)
    Short name:
    AK 2
    Alternative name(s):
    Adenylate monophosphate kinase
    ATP:AMP phosphotransferase
    ATP-AMP transphosphorylase 2
  • Recommended name:
    Adenylate kinase (EC:2.7.4.3)
    Alternative name(s):
    Adenylate kinase cytosolic and mitochondrial
    Adenylate monophosphate kinase
    ATP-AMP transphosphorylase
    ATP:AMP phosphotransferase

Gene namesi

  • Name:ADK1
  • Name:Adk2
  • Name:AK2
  • Name:let-754

Subcellular locationi

Catalytic activityi

  • ATP + AMP = 2 ADP.

Domaini

  • Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Functioni

  • Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
  • Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.

Sequence similaritiesi

Subunit structurei

  • Monomer.

Modified residuei

  • N-acetylserine (to residues corresponding to position 3)

Regioni

  • NMPbind (to residues corresponding to positions 36 - 65)
  • LID (to residues corresponding to positions 133 - 170)

Disulfide bondi

  • (to residues corresponding to positions 42 - 92)

Propeptidei

  • Removed in mature form (to residues corresponding to positions 1 - 2)

Binding sitei

  • AMP (to residues corresponding to position 37)
  • AMP (to residues corresponding to position 42)
  • AMP (to residues corresponding to position 99)
  • ATP (to residues corresponding to position 134)
  • AMP (to residues corresponding to position 167)
  • AMP (to residues corresponding to position 178)
  • ATP; via carbonyl oxygen (to residues corresponding to position 206)

Nucleotide bindingi

  • ATP (to residues corresponding to positions 16 - 21)
  • AMP (to residues corresponding to positions 63 - 65)
  • AMP (to residues corresponding to positions 92 - 95)
  • ATP (to residues corresponding to positions 143 - 144)

Initiator methioninei

  • Removed (to residues corresponding to position 1)

Keywordsi

GO (Gene Ontology) termsi