Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 6 - 14 aligns to entry P59846 (individually applies "ATP")
    • Subsequence at position 33 - 33 aligns to "A" in entry P59846 (individually applies "ATP; via amide nitrogen and carbonyl oxygen")
    • Subsequence at position 84 - 84 aligns to "Y" in entry P59846 (individually applies "Citrulline")
    • Subsequence at position 89 - 89 aligns to "S" in entry P59846 (individually applies "Citrulline")
    • Subsequence at position 114 - 114 aligns to "G" in entry P59846 (individually applies "ATP; via amide nitrogen")
    • Subsequence at position 116 - 116 aligns to "T" in entry P59846 (individually applies "Aspartate")
    • Subsequence at position 120 - 120 aligns to "N" in entry P59846 (individually applies "Aspartate")
    • Subsequence at position 120 - 120 aligns to "N" in entry P59846 (individually applies "Citrulline")
    • Subsequence at position 121 - 121 aligns to "D" in entry P59846 (individually applies "Aspartate")
    • Subsequence at position 124 - 124 aligns to "R" in entry P59846 (individually applies "Citrulline")
    • Subsequence at position 173 - 173 aligns to "S" in entry P59846 (individually applies "Citrulline")
    • Subsequence at position 182 - 182 aligns to "S" in entry P59846 (individually applies "Citrulline")
    • Subsequence at position 258 - 258 aligns to "E" in entry P59846 (individually applies "Citrulline")
    • Subsequence at position 270 - 270 aligns to "Y" in entry P59846 (individually applies "Citrulline")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase

Gene namei

  • Name:argG

Subunit structurei

  • Homotetramer.

Pathwayi

  • Pathwayi: L-arginine biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate. This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.

Subcellular locationi

Sequence similaritiesi

Catalytic activityi

  • ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

Nucleotide bindingi

  • ATP (to residues corresponding to positions 6 - 14)

Binding sitei

  • ATP; via amide nitrogen and carbonyl oxygen (to residues corresponding to position 33)
  • Citrulline (to residues corresponding to position 84)
  • Citrulline (to residues corresponding to position 89)
  • ATP; via amide nitrogen (to residues corresponding to position 114)
  • Aspartate (to residues corresponding to position 116)
  • Aspartate (to residues corresponding to position 120)
  • Citrulline (to residues corresponding to position 120)
  • Aspartate (to residues corresponding to position 121)
  • Citrulline (to residues corresponding to position 124)
  • Citrulline (to residues corresponding to position 173)
  • Citrulline (to residues corresponding to position 182)
  • Citrulline (to residues corresponding to position 258)
  • Citrulline (to residues corresponding to position 270)

Keywordsi

GO (Gene Ontology) termsi