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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01970
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 227 - 227 aligns to "K" in entry P83788
    • Subsequence at position 227 - 227 aligns to "K" in entry P83788
    • Subsequence at position 97 - 97 aligns to "[TIL]" in entry P83788 (individually applies "Pyridoxal phosphate; via amide nitrogen")
    • Subsequence at position 98 - 98 aligns to "[ST]" in entry P83788 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 129 - 132 aligns to "F-P-[ST]-D" in entry P83788 (individually applies "Pyridoxal phosphate binding")
    • Subsequence at position 172 - 172 aligns to "T" in entry P83788 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 201 - 201 aligns to "D" in entry P83788 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 204 - 204 aligns to "H" in entry P83788 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 226 - 226 aligns to "Y" in entry P83788 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 256 - 256 aligns to "W" in entry P83788 (individually applies "Pyridoxal phosphate")
    • Subsequence at position 282 - 282 aligns to "[TN]" in entry P83788 (individually applies "Pyridoxal phosphate")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Kynureninase (EC:3.7.1.3)
    Alternative name(s):
    L-kynurenine hydrolase

Gene namei

  • Name:kynU

Catalytic activityi

  • L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.
  • L-kynurenine + H2O = anthranilate + L-alanine.

Cofactori

Sequence similaritiesi

Functioni

  • Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.

Pathwayi

  • Pathwayi: L-kynurenine degradation

    This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine. This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
  • Pathwayi: NAD(+) biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine. This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.

Subunit structurei

  • Homodimer.

Regioni

  • Pyridoxal phosphate binding (to residues corresponding to positions 129 - 132)

Modified residuei

  • N6-(pyridoxal phosphate)lysine (to residues corresponding to position 227)

Binding sitei

  • Pyridoxal phosphate; via amide nitrogen (to residues corresponding to position 97)
  • Pyridoxal phosphate (to residues corresponding to position 98)
  • Pyridoxal phosphate (to residues corresponding to position 172)
  • Pyridoxal phosphate (to residues corresponding to position 201)
  • Pyridoxal phosphate (to residues corresponding to position 204)
  • Pyridoxal phosphate (to residues corresponding to position 226)
  • Pyridoxal phosphate (to residues corresponding to position 256)
  • Pyridoxal phosphate (to residues corresponding to position 282)

Keywordsi

GO (Gene Ontology) termsi