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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 247 - 247 aligns to "C" in entry P00497 Subsequence at position 393 - 393 aligns to "C" in entry P00497 Subsequence at position 448 - 448 aligns to "C" in entry P00497 Subsequence at position 451 - 451 aligns to "C" in entry P00497
    • Subsequence at position 294 - 294 aligns to "[ST]" in entry P00497 Subsequence at position 356 - 356 aligns to "D" in entry P00497 Subsequence at position 357 - 357 aligns to "D" in entry P00497
    • Subsequence at position 12 - 12 aligns to "C" in entry P00497
  • Subsequence at position 294 - 294 aligns to "[ST]" in entry P00497 (applies "Magnesium") Subsequence at position 356 - 356 aligns to "D" in entry P00497 (applies "Magnesium") Subsequence at position 357 - 357 aligns to "D" in entry P00497 (applies "Magnesium")
  • Subsequence at position 247 - 247 aligns to "C" in entry P00497 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 393 - 393 aligns to "C" in entry P00497 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 448 - 448 aligns to "C" in entry P00497 (applies "Iron-sulfur (4Fe-4S)") Subsequence at position 451 - 451 aligns to "C" in entry P00497 (applies "Iron-sulfur (4Fe-4S)")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Amidophosphoribosyltransferase (EC:2.4.2.14)
    Short name:
    ATase
    Alternative name(s):
    Glutamine phosphoribosylpyrophosphate amidotransferase
    Short name:
    GPATase

Gene namei

  • Name:purF

Catalytic activityi

  • 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.

Functioni

  • Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Pathwayi

  • Pathwayi: IMP biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate. This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Cofactori

Sequence similaritiesi

Active sitei

  • Nucleophile (to residues corresponding to position 12)

Metal bindingi

  • Magnesium (to residues corresponding to position 294)
  • Magnesium (to residues corresponding to position 356)
  • Magnesium (to residues corresponding to position 357)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 247)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 393)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 448)
  • Iron-sulfur (4Fe-4S) (to residues corresponding to position 451)

Keywordsi

GO (Gene Ontology) termsi