Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

The annotation and conditions in this rule are derived from the following entries: P0AG18 (PURE_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 16 - 16 aligns to "S" in entry P0AG18 (individually applies "Substrate")
    • Subsequence at position 19 - 19 aligns to "D" in entry P0AG18 (individually applies "Substrate")
    • Subsequence at position 46 - 46 aligns to "R" in entry P0AG18 (individually applies "Substrate")

... then these annotations are applied i

Protein namei

  • Recommended name:
    N5-carboxyaminoimidazole ribonucleotide mutase (EC:5.4.99.18)
    Short name:
    N5-CAIR mutase
    Alternative name(s):
    5-(carboxyamino)imidazole ribonucleotide mutase

Gene namei

  • Name:purE

Sequence similaritiesi

Catalytic activityi

  • 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.

Functioni

  • Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

Pathwayi

  • Pathwayi: IMP biosynthesis via de novo pathway

    This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route). This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Binding sitei

  • Substrate (to residues corresponding to position 16)
  • Substrate (to residues corresponding to position 19)
  • Substrate (to residues corresponding to position 46)

Keywordsi

GO (Gene Ontology) termsi

  • GO:0006189 'de novo' IMP biosynthetic process
  • GO:0034023 5-(carboxyamino)imidazole ribonucleotide mutase activity

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health