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The annotation and conditions in this rule are derived from the following entries: Q8WUI4 (HDAC7_HUMAN), Q9UKV0 (HDAC9_HUMAN), Q9Z2V6 (HDAC5_MOUSE), P56524 (HDAC4_HUMAN), Q8C2B3 (HDAC7_MOUSE), Q9UQL6 (HDAC5_HUMAN)

If a protein meets these conditions... i

Common conditions

    • Matches PIR Superfamily signature PIRSF037911
    • sequence length = 768 - 1255
    • taxon = Metazoa
    • fragment ≠ the sequence is fragmented

... then these annotations are applied i

Protein namei

  • Recommended name:
    Histone deacetylase (EC:

Subcellular locationi

Sequence similaritiesi

Catalytic activityi

  • Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.


  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.


GO (Gene Ontology) termsi

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