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If a protein meets these conditions... i

Common conditions

    • Matches PIR Superfamily signature PIRSF037911
    • sequence length = 768 - 1255
    • taxon = Metazoa
    • fragment ≠ the sequence is fragmented

... then these annotations are applied i

Protein namei

  • Recommended name:
    Histone deacetylase (EC:3.5.1.98)

Subcellular locationi

Functioni

  • Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Sequence similaritiesi

Catalytic activityi

  • Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Keywordsi

GO (Gene Ontology) termsi