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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00965
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 404 - @CTER@ aligns to entry P42305

... then these annotations are applied i

Protein namei

  • Recommended name:
    ATP-dependent RNA helicase DbpA (EC:

Gene namei

  • Name:dbpA

Catalytic activityi

  • ATP + H2O = ADP + phosphate.


  • DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.

Subcellular locationi


  • Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.

Sequence similaritiesi


  • Involved in 23S rRNA binding (to residues corresponding to positions 404 - @CTER@i)


GO (Gene Ontology) termsi