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If a protein meets these conditions... i

Common conditions

Special conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Protein argonaute-3
    Short name:
    Alternative name(s):
    Eukaryotic translation initiation factor 2C 3
    Short name:
    eIF-2C 3
    Short name:
    eIF2C 3

Gene namei

  • Name:EIF2C3, Synonym:AGO3

Subcellular locationi

Subunit structurei

  • Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.

Sequence similaritiesi


  • Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.


GO (Gene Ontology) termsi