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If a protein meets these conditions... i

Common conditions

Special conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Protein argonaute-3
    Short name:
    Argonaute3
    Alternative name(s):
    Eukaryotic translation initiation factor 2C 3
    Short name:
    eIF-2C 3
    Short name:
    eIF2C 3

Gene namei

  • Name:EIF2C3, Synonym:AGO3

Subcellular locationi

Functioni

  • Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

Subunit structurei

  • Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.

Sequence similaritiesi

Keywordsi

GO (Gene Ontology) termsi