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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00825
    • taxon = Eukaryota
    • fragment ≠ the sequence is fragmented

Special conditions

    • taxon = Metazoa Subsequence at position 47 - 47 aligns to "H" in entry Q0VCA8 Subsequence at position 53 - 53 aligns to "E" in entry Q0VCA8 Subsequence at position 91 - 91 aligns to "H" in entry Q0VCA8
    • taxon = Fungi Subsequence at position 49 - 49 aligns to "H" in entry P47096 Subsequence at position 55 - 55 aligns to "E" in entry P47096 Subsequence at position 97 - 97 aligns to "H" in entry P47096
    • taxon = Metazoa Subsequence at position 47 - 47 aligns to "H" in entry Q0VCA8 Subsequence at position 53 - 53 aligns to "E" in entry Q0VCA8 Subsequence at position 91 - 91 aligns to "H" in entry Q0VCA8
    • taxon = Fungi Subsequence at position 49 - 49 aligns to "H" in entry P47096 Subsequence at position 55 - 55 aligns to "E" in entry P47096 Subsequence at position 97 - 97 aligns to "H" in entry P47096
    • taxon = Fungi Subsequence at position 126 - 126 aligns to "C" in entry P47096 Subsequence at position 129 - 129 aligns to "C" in entry P47096 Subsequence at position 163 - 163 aligns to "C" in entry P47096 Subsequence at position 166 - 166 aligns to "C" in entry P47096
  • taxon = Fungi Subsequence at position 126 - 126 aligns to "C" in entry P47096 (applies "Divalent metal cation") Subsequence at position 129 - 129 aligns to "C" in entry P47096 (applies "Divalent metal cation") Subsequence at position 163 - 163 aligns to "C" in entry P47096 (applies "Divalent metal cation") Subsequence at position 166 - 166 aligns to "C" in entry P47096 (applies "Divalent metal cation")
  • taxon = Metazoa Subsequence at position 47 - 47 aligns to "H" in entry Q0VCA8 (applies "Iron; catalytic") Subsequence at position 53 - 53 aligns to "E" in entry Q0VCA8 (applies "Iron; catalytic") Subsequence at position 91 - 91 aligns to "H" in entry Q0VCA8 (applies "Iron; catalytic")
    • taxon = Fungi
    • Subsequence at position 45 - 45 aligns to "R" in entry P47096 (individually applies "Dioxygen")
    • Subsequence at position 55 - 55 aligns to "E" in entry P47096 (individually applies "Substrate")
    • Subsequence at position 101 - 101 aligns to "R" in entry P47096 (individually applies "Substrate")
    • Subsequence at position 111 - 111 aligns to "E" in entry P47096 (individually applies "Substrate")
  • taxon = Fungi Subsequence at position 49 - 49 aligns to "H" in entry P47096 (applies "Iron; catalytic") Subsequence at position 55 - 55 aligns to "E" in entry P47096 (applies "Iron; catalytic") Subsequence at position 97 - 97 aligns to "H" in entry P47096 (applies "Iron; catalytic")
    • taxon = Metazoa
    • Subsequence at position 43 - 43 aligns to "R" in entry Q0VCA8 (individually applies "Dioxygen")
    • Subsequence at position 53 - 53 aligns to "E" in entry Q0VCA8 (individually applies "Substrate")
    • Subsequence at position 95 - 95 aligns to "R" in entry Q0VCA8 (individually applies "Substrate")
    • Subsequence at position 105 - 105 aligns to "E" in entry Q0VCA8 (individually applies "Substrate")
    • Subsequence at position 161 - 177 aligns to entry Q0VCA8 (individually applies "Linker")
    • Subsequence at position 178 - @CTER|+1@ aligns to entry Q0VCA8 (individually applies "Domain B")
    • Subsequence at position @NTER|+1@ - 160 aligns to entry Q0VCA8 (individually applies "Domain A (catalytic)")

... then these annotations are applied i

Protein namesi

  • Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
    Alternative name(s):
    Biosynthesis of nicotinic acid protein 1
    3-hydroxyanthranilate oxygenase
    Short name:
    3-HAO
    3-hydroxyanthranilic acid dioxygenase
    Short name:
    HAD
  • Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
    Alternative name(s):
    3-hydroxyanthranilate oxygenase
    Short name:
    3-HAO
    3-hydroxyanthranilic acid dioxygenase
    Short name:
    HAD

Gene namesi

  • Name:BNA1
  • Name:HAAO

Catalytic activityi

  • 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.

Sequence similaritiesi

Subcellular locationi

Cofactori

Functioni

  • Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

Subunit structurei

  • Monomer.

Pathwayi

  • Pathwayi: NAD(+) biosynthesis

    This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine. This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.

Regioni

  • Linker (to residues corresponding to positions 161 - 177)
  • Domain B (to residues corresponding to positions 178 - @CTER|+1@i)
  • Domain A (catalytic) (to residues corresponding to positions @NTER|+1@i - 160)

Binding sitei

  • Dioxygen (to residues corresponding to position 45)
  • Substrate (to residues corresponding to position 55)
  • Substrate (to residues corresponding to position 101)
  • Substrate (to residues corresponding to position 111)
  • Dioxygen (to residues corresponding to position 43)
  • Substrate (to residues corresponding to position 53)
  • Substrate (to residues corresponding to position 95)
  • Substrate (to residues corresponding to position 105)

Metal bindingi

  • Divalent metal cation (to residues corresponding to position 126)
  • Divalent metal cation (to residues corresponding to position 129)
  • Divalent metal cation (to residues corresponding to position 163)
  • Divalent metal cation (to residues corresponding to position 166)
  • Iron; catalytic (to residues corresponding to position 47)
  • Iron; catalytic (to residues corresponding to position 53)
  • Iron; catalytic (to residues corresponding to position 91)
  • Iron; catalytic (to residues corresponding to position 49)
  • Iron; catalytic (to residues corresponding to position 55)
  • Iron; catalytic (to residues corresponding to position 97)

Keywordsi

GO (Gene Ontology) termsi