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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00581
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 17 - 25 aligns to entry P0A6E4 (individually applies "ATP")
    • Subsequence at position 43 - 43 aligns to "A" in entry P0A6E4 (individually applies "ATP; via amide nitrogen and carbonyl oxygen")
    • Subsequence at position 99 - 99 aligns to "Y" in entry P0A6E4 (individually applies "Citrulline")
    • Subsequence at position 129 - 129 aligns to "G" in entry P0A6E4 (individually applies "ATP; via amide nitrogen")
    • Subsequence at position 131 - 131 aligns to "T" in entry P0A6E4 (individually applies "ATP")
    • Subsequence at position 131 - 131 aligns to "T" in entry P0A6E4 (individually applies "Aspartate")
    • Subsequence at position 135 - 135 aligns to "N" in entry P0A6E4 (individually applies "Aspartate")
    • Subsequence at position 135 - 135 aligns to "N" in entry P0A6E4 (individually applies "Citrulline")
    • Subsequence at position 136 - 136 aligns to "D" in entry P0A6E4 (individually applies "ATP")
    • Subsequence at position 136 - 136 aligns to "D" in entry P0A6E4 (individually applies "Aspartate")
    • Subsequence at position 139 - 139 aligns to "R" in entry P0A6E4 (individually applies "Citrulline")
    • Subsequence at position 192 - 192 aligns to "S" in entry P0A6E4 (individually applies "Citrulline")
    • Subsequence at position 194 - 194 aligns to "D" in entry P0A6E4 (individually applies "ATP")
    • Subsequence at position 201 - 201 aligns to "T" in entry P0A6E4 (individually applies "Citrulline")
    • Subsequence at position 203 - 203 aligns to "E" in entry P0A6E4 (individually applies "Citrulline")
    • Subsequence at position 280 - 280 aligns to "E" in entry P0A6E4 (individually applies "Citrulline")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase

Gene namei

  • Name:argG

Subunit structurei

  • Homotetramer.

Pathwayi

  • Pathwayi: L-arginine biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate. This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.

Subcellular locationi

Sequence similaritiesi

Catalytic activityi

  • ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

Nucleotide bindingi

  • ATP (to residues corresponding to positions 17 - 25)

Binding sitei

  • ATP; via amide nitrogen and carbonyl oxygen (to residues corresponding to position 43)
  • Citrulline (to residues corresponding to position 99)
  • ATP; via amide nitrogen (to residues corresponding to position 129)
  • ATP (to residues corresponding to position 131)
  • Aspartate (to residues corresponding to position 131)
  • Aspartate (to residues corresponding to position 135)
  • Citrulline (to residues corresponding to position 135)
  • ATP (to residues corresponding to position 136)
  • Aspartate (to residues corresponding to position 136)
  • Citrulline (to residues corresponding to position 139)
  • Citrulline (to residues corresponding to position 192)
  • ATP (to residues corresponding to position 194)
  • Citrulline (to residues corresponding to position 201)
  • Citrulline (to residues corresponding to position 203)
  • Citrulline (to residues corresponding to position 280)

Keywordsi

GO (Gene Ontology) termsi