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The annotation and conditions in this rule are derived from the following entries: P69922 (FUCI_ECOLI)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01254
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 337 - 337 aligns to "E" in entry P69922
    • Subsequence at position 361 - 361 aligns to "D" in entry P69922
    • Subsequence at position 528 - 528 aligns to "H" in entry P69922
    • Subsequence at position 337 - 337 aligns to "E" in entry P69922 (individually applies "Proton acceptor")
    • Subsequence at position 361 - 361 aligns to "D" in entry P69922 (individually applies "Proton acceptor")
    • Subsequence at position 337 - 337 aligns to "E" in entry P69922
    • Subsequence at position 528 - 528 aligns to "H" in entry P69922
    • Subsequence at position 361 - 361 aligns to "D" in entry P69922

... then these annotations are applied i

Protein namei

  • Recommended name:
    L-fucose isomerase (EC:5.3.1.25)
    Short name:
    FucIase
    Alternative name(s):
    6-deoxy-L-galactose isomerase

Gene namei

  • Name:fucI

Functioni

  • Converts the aldose L-fucose into the corresponding ketose L-fuculose.

Cofactori

Subunit structurei

  • Homohexamer.

Pathwayi

  • Pathwayi: L-fucose degradation

    This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose. This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Catalytic activityi

  • L-fucopyranose = L-fuculose.

Sequence similaritiesi

Subcellular locationi

Active sitei

  • Proton acceptor (to residues corresponding to position 337)
  • Proton acceptor (to residues corresponding to position 361)

Metal bindingi

  • Manganese (to residues corresponding to position 337)
  • Manganese (to residues corresponding to position 528)
  • Manganese (to residues corresponding to position 361)

Keywordsi

GO (Gene Ontology) termsi