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The annotation and conditions in this rule are derived from the following entries: P62707 (GPMA_ECOLI), Q3JWH7 (GPMA_BURP1), P9WIC9 (GPMA_MYCTU)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 10 - 17 aligns to "R-H-G-x-S-x(2)-[NK]" in entry P62707 (individually applies "Substrate binding")
    • Subsequence at position 11 - 11 aligns to "H" in entry P62707 (individually applies "Tele-phosphohistidine intermediate")
    • Subsequence at position 23 - 24 aligns to "[TS]-G" in entry P62707 (individually applies "Substrate binding")
    • Subsequence at position 62 - 62 aligns to "R" in entry P62707 (individually applies "Substrate")
    • Subsequence at position 89 - 89 aligns to "E" in entry P62707 (individually applies "Proton donor/acceptor")
    • Subsequence at position 89 - 92 aligns to "E-[RK]-x-Y" in entry P62707 (individually applies "Substrate binding")
    • Subsequence at position 100 - 100 aligns to "K" in entry P62707 (individually applies "Substrate")
    • Subsequence at position 116 - 117 aligns to "R-R" in entry P62707 (individually applies "Substrate binding")
    • Subsequence at position 184 - 184 aligns to "H" in entry P62707 (individually applies "Transition state stabilizer")
    • Subsequence at position 185 - 186 aligns to "G-N" in entry P62707 (individually applies "Substrate binding")

... then these annotations are applied i

Protein namei

  • Recommended name:
    2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (EC:5.4.2.11)
    Short name:
    BPG-dependent PGAM
    Short name:
    PGAM
    Short name:
    Phosphoglyceromutase
    Short name:
    dPGM

Gene namei

  • Name:gpmA

Catalytic activityi

  • 2-phospho-D-glycerate = 3-phospho-D-glycerate.

Sequence similaritiesi

Functioni

  • Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

Pathwayi

  • Pathwayi: glycolysis

    This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate. This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Subunit structurei

  • Homodimer.

Binding sitei

  • Substrate (to residues corresponding to position 62)
  • Substrate (to residues corresponding to position 100)

Active sitei

  • Tele-phosphohistidine intermediate (to residues corresponding to position 11)
  • Proton donor/acceptor (to residues corresponding to position 89)

Sitei

  • Transition state stabilizer (to residues corresponding to position 184)

Regioni

  • Substrate binding (to residues corresponding to positions 10 - 17)
  • Substrate binding (to residues corresponding to positions 23 - 24)
  • Substrate binding (to residues corresponding to positions 89 - 92)
  • Substrate binding (to residues corresponding to positions 116 - 117)
  • Substrate binding (to residues corresponding to positions 185 - 186)

Keywordsi

GO (Gene Ontology) termsi

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