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The annotation and conditions in this rule are derived from the following entries: P06988 (HISX_ECOLI), P10370 (HISX_SALTY)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 259 - 259 aligns to "[EQ]" in entry P06988 Subsequence at position 262 - 262 aligns to "H" in entry P06988 Subsequence at position 360 - 360 aligns to "D" in entry P06988 Subsequence at position 419 - 419 aligns to "H" in entry P06988
    • Subsequence at position 326 - 326 aligns to "E" in entry P06988 (individually applies "Proton acceptor")
    • Subsequence at position 327 - 327 aligns to "H" in entry P06988 (individually applies "Proton acceptor")
  • Subsequence at position 130 - 130 aligns to "Y" in entry P06988 (applies "NAD") Subsequence at position 188 - 188 aligns to "Q" in entry P06988 (applies "NAD") Subsequence at position 211 - 211 aligns to "N" in entry P06988 (applies "NAD")
  • Subsequence at position 237 - 237 aligns to "[ST]" in entry P06988 (applies "Substrate") Subsequence at position 259 - 259 aligns to "Q" in entry P06988 (applies "Substrate") Subsequence at position 262 - 262 aligns to "H" in entry P06988 (applies "Substrate") Subsequence at position 327 - 327 aligns to "H" in entry P06988 (applies "Substrate") Subsequence at position 360 - 360 aligns to "D" in entry P06988 (applies "Substrate") Subsequence at position 414 - 414 aligns to "E" in entry P06988 (applies "Substrate") Subsequence at position 419 - 419 aligns to "H" in entry P06988 (applies "Substrate")
  • Subsequence at position 259 - 259 aligns to "[EQ]" in entry P06988 (applies "Zinc") Subsequence at position 262 - 262 aligns to "H" in entry P06988 (applies "Zinc") Subsequence at position 360 - 360 aligns to "D" in entry P06988 (applies "Zinc") Subsequence at position 419 - 419 aligns to "H" in entry P06988 (applies "Zinc")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH

Gene namei

  • Name:hisD

Sequence similaritiesi

Pathwayi

  • Pathwayi: L-histidine biosynthesis

    This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate. This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Subunit structurei

  • Homodimer.

Cofactori

  • Zn2+Note: Binds 1 zinc ion per subunit.

Catalytic activityi

  • L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Functioni

  • Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Binding sitei

  • NAD (to residues corresponding to position 130)
  • NAD (to residues corresponding to position 188)
  • NAD (to residues corresponding to position 211)
  • Substrate (to residues corresponding to position 237)
  • Substrate (to residues corresponding to position 259)
  • Substrate (to residues corresponding to position 262)
  • Substrate (to residues corresponding to position 327)
  • Substrate (to residues corresponding to position 360)
  • Substrate (to residues corresponding to position 414)
  • Substrate (to residues corresponding to position 419)

Active sitei

  • Proton acceptor (to residues corresponding to position 326)
  • Proton acceptor (to residues corresponding to position 327)

Metal bindingi

  • Zinc (to residues corresponding to position 259)
  • Zinc (to residues corresponding to position 262)
  • Zinc (to residues corresponding to position 360)
  • Zinc (to residues corresponding to position 419)

Keywordsi

GO (Gene Ontology) termsi

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