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The annotation and conditions in this rule are derived from the following entries: Q9X0C7 (HIS4_THEMA), P16250 (HIS4_STRCO), P9WMM5 (HIS4_MYCTU)

If a protein meets these conditions... i

Common conditions

Special conditions

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Phosphoribosyl isomerase A
    Alternative name(s):
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
  • Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
    Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene namesi

  • Name:priA, Synonym:hisA
  • Name:hisA

Subcellular locationi

Sequence similaritiesi

Pathwayi

  • Pathwayi: L-histidine biosynthesis

    This protein is involved in step 4 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate. This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.
  • Pathwayi: L-tryptophan biosynthesis

    This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate. This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Functioni

  • Involved in both the histidine and tryptophan biosynthetic pathways.

Catalytic activityi

  • 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.
  • N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Active sitei

  • Proton acceptor (to residues corresponding to position 8)
  • Proton donor (to residues corresponding to position 127)

Keywordsi

GO (Gene Ontology) termsi

  • GO:0000105 histidine biosynthetic process
  • GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
  • GO:0005737 cytoplasm
  • GO:0000162 tryptophan biosynthetic process
  • GO:0004640 phosphoribosylanthranilate isomerase activity