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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 104 - 106 aligns to "S-x-T" in entry P9WN93 (individually applies "Substrate binding")
    • Subsequence at position 128 - 131 aligns to "[HN]-x-N-D" in entry P9WN93 (individually applies "Substrate binding (B site)")
    • Subsequence at position 138 - 140 aligns to "S-[ST]-N" in entry P9WN93 (individually applies "Substrate binding")
    • Subsequence at position 186 - 186 aligns to "T" in entry P9WN93 (individually applies "Substrate")
    • Subsequence at position 187 - 187 aligns to "H" in entry P9WN93 (individually applies "Proton donor/acceptor")
    • Subsequence at position 318 - 318 aligns to "S" in entry P9WN93 (individually applies "")
    • Subsequence at position 319 - 319 aligns to "S" in entry P9WN93 (individually applies "Substrate")
    • Subsequence at position 324 - 326 aligns to "K-x-N" in entry P9WN93 (individually applies "Substrate binding")
    • Subsequence at position 331 - 331 aligns to "E" in entry P9WN93 (individually applies "Important for catalytic activity")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Fumarate hydratase class II (EC:4.2.1.2)
    Short name:
    Fumarase C
    Alternative name(s):
    Iron-independent fumarase
    Aerobic fumarase

Gene namei

  • Name:fumC

Miscellaneousi

  • There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Catalytic activityi

  • (S)-malate = fumarate + H2O.

Functioni

  • Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Pathwayi

  • Pathwayi: tricarboxylic acid cycle

    This protein is involved in step 1 of the subpathway that synthesizes (S)-malate from fumarate. This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from fumarate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Subcellular locationi

Sequence similaritiesi

Subunit structurei

  • Homotetramer.

Active sitei

  • Proton donor/acceptor (to residues corresponding to position 187)
  • (to residues corresponding to position 318)

Sitei

  • Important for catalytic activity (to residues corresponding to position 331)

Binding sitei

  • Substrate (to residues corresponding to position 186)
  • Substrate (to residues corresponding to position 319)

Regioni

  • Substrate binding (to residues corresponding to positions 104 - 106)
  • Substrate binding (B site) (to residues corresponding to positions 128 - 131)
  • Substrate binding (to residues corresponding to positions 138 - 140)
  • Substrate binding (to residues corresponding to positions 324 - 326)

Keywordsi

GO (Gene Ontology) termsi