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The annotation and conditions in this rule are derived from the following entries: P33195 (GCSP_ECOLI)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00711
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 708 - 708 aligns to "K" in entry P33195

... then these annotations are applied i

Protein namei

  • Recommended name:
    Glycine dehydrogenase (decarboxylating) (EC:
    Alternative name(s):
    Glycine decarboxylase
    Glycine dehydrogenase (aminomethyl-transferring)
    Glycine cleavage system P-protein

Gene namei

  • Name:gcvP

Subunit structurei

  • The glycine cleavage system is composed of four proteins: P, T, L and H.


Catalytic activityi

  • Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.

Sequence similaritiesi


  • The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Modified residuei

  • N6-(pyridoxal phosphate)lysine (to residues corresponding to position 708)


GO (Gene Ontology) termi

  • GO:0019464 glycine decarboxylation via glycine cleavage system