Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

The annotation and conditions in this rule are derived from the following entries: P33195 (GCSP_ECOLI)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00711
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 708 - 708 aligns to "K" in entry P33195

... then these annotations are applied i

Protein namei

  • Recommended name:
    Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
    Alternative name(s):
    Glycine decarboxylase
    Glycine dehydrogenase (aminomethyl-transferring)
    Glycine cleavage system P-protein

Gene namei

  • Name:gcvP

Subunit structurei

  • The glycine cleavage system is composed of four proteins: P, T, L and H.

Cofactori

Catalytic activityi

  • Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.

Sequence similaritiesi

Functioni

  • The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Modified residuei

  • N6-(pyridoxal phosphate)lysine (to residues corresponding to position 708)

Keywordsi

GO (Gene Ontology) termi

  • GO:0019464 glycine decarboxylation via glycine cleavage system