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The annotation and conditions in this rule are derived from the following entries: P0AGJ9 (SYY_ECOLI), P00952 (SYY_GEOSE), P41256 (SYY_ACIFR), Q57834 (SYY_METJA), O29482 (SYY_ARCFU), Q9YA64 (SYY_AERPE), O58739 (SYY_PYRHO)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 39 - 39 aligns to "Y" in entry Q9YA64 (individually applies "Tyrosine")
    • Subsequence at position 165 - 165 aligns to "Y" in entry Q9YA64 (individually applies "Tyrosine")
    • Subsequence at position 169 - 169 aligns to "Q" in entry Q9YA64 (individually applies "Tyrosine")
    • Subsequence at position 172 - 172 aligns to "D" in entry Q9YA64 (individually applies "Tyrosine")
    • Subsequence at position 187 - 187 aligns to "Q" in entry Q9YA64 (individually applies "Tyrosine")
    • Subsequence at position 238 - 242 aligns to "K-M-S-K-S" in entry Q9YA64 (individually applies ""KMSKS" region")
    • Subsequence at position 241 - 241 aligns to "K" in entry Q9YA64 (individually applies "ATP")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Tyrosine--tRNA ligase (EC:6.1.1.1)
    Alternative name(s):
    Tyrosyl-tRNA synthetase
    Short name:
    TyrRS

Gene namei

  • Name:tyrS

Subcellular locationi

Sequence similaritiesi

Subunit structurei

  • Homodimer.

Functioni

  • Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Catalytic activityi

  • ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).

Motifi

  • "KMSKS" region (to residues corresponding to positions 238 - 242)

Binding sitei

  • Tyrosine (to residues corresponding to position 39)
  • Tyrosine (to residues corresponding to position 165)
  • Tyrosine (to residues corresponding to position 169)
  • Tyrosine (to residues corresponding to position 172)
  • Tyrosine (to residues corresponding to position 187)
  • ATP (to residues corresponding to position 241)

Keywordsi

GO (Gene Ontology) termsi