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The annotation and conditions in this rule are derived from the following entries: Q9AEM1 (PCKG_CORGL), Q9AGJ6 (PCKG_MYCSM), Q6F494 (PCKG_THEKO), A5TYT6 (PCKG_MYCTA)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 229 - 229 aligns to "K" in entry A5TYT6 Subsequence at position 249 - 249 aligns to "H" in entry A5TYT6 Subsequence at position 296 - 296 aligns to "D" in entry A5TYT6
  • Subsequence at position 229 - 229 aligns to "K" in entry A5TYT6 (applies "Manganese") Subsequence at position 249 - 249 aligns to "H" in entry A5TYT6 (applies "Manganese; via tele nitrogen") Subsequence at position 296 - 296 aligns to "D" in entry A5TYT6 (applies "Manganese")
    • Subsequence at position 81 - 81 aligns to "R" in entry A5TYT6 (individually applies "Substrate")
    • Subsequence at position 220 - 222 aligns to "Y-x-G" in entry A5TYT6 (individually applies "Substrate binding")
    • Subsequence at position 271 - 271 aligns to "S" in entry A5TYT6 (individually applies "Substrate")
    • Subsequence at position 272 - 277 aligns to "[AGSQM]-[CS]-G-K-T-[NS]" in entry A5TYT6 (individually applies "GTP")
    • Subsequence at position 273 - 273 aligns to "[CS]" in entry A5TYT6 (individually applies "")
    • Subsequence at position 387 - 389 aligns to "N-x-R" in entry A5TYT6 (individually applies "Substrate binding")
    • Subsequence at position 389 - 389 aligns to "R" in entry A5TYT6 (individually applies "GTP")
    • Subsequence at position 420 - 420 aligns to "R" in entry A5TYT6 (individually applies "GTP")
    • Subsequence at position 515 - 518 aligns to "[FY]-x-x-N" in entry A5TYT6 (individually applies "GTP")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
    Short name:
    PEP carboxykinase
    Short name:
    PEPCK
    Alternative name(s):
    GTP-dependent phosphoenolpyruvate carboxykinase
    Short name:
    GTP-PEPCK

Gene namei

  • Name:pckG

Subcellular locationi

Pathwayi

  • Pathwayi: gluconeogenesis

    This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
    View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Catalytic activityi

  • GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.

Subunit structurei

  • Monomer.

Sequence similaritiesi

Cofactori

  • Mn2+Note: Binds 1 Mn2+ ion per subunit.

Functioni

  • Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Regioni

  • Substrate binding (to residues corresponding to positions 220 - 222)
  • Substrate binding (to residues corresponding to positions 387 - 389)

Active sitei

  • (to residues corresponding to position 273)

Nucleotide bindingi

  • GTP (to residues corresponding to positions 272 - 277)
  • GTP (to residues corresponding to positions 515 - 518)

Binding sitei

  • Substrate (to residues corresponding to position 81)
  • Substrate (to residues corresponding to position 271)
  • GTP (to residues corresponding to position 389)
  • GTP (to residues corresponding to position 420)

Metal bindingi

  • Manganese (to residues corresponding to position 229)
  • Manganese; via tele nitrogen (to residues corresponding to position 249)
  • Manganese (to residues corresponding to position 296)

Keywordsi

GO (Gene Ontology) termsi

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