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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 229 - 229 aligns to "K" in entry A5TYT6 Subsequence at position 249 - 249 aligns to "H" in entry A5TYT6 Subsequence at position 296 - 296 aligns to "D" in entry A5TYT6
  • Subsequence at position 229 - 229 aligns to "K" in entry A5TYT6 (applies "Manganese") Subsequence at position 249 - 249 aligns to "H" in entry A5TYT6 (applies "Manganese; via tele nitrogen") Subsequence at position 296 - 296 aligns to "D" in entry A5TYT6 (applies "Manganese")
    • Subsequence at position 81 - 81 aligns to "R" in entry A5TYT6 (individually applies "Substrate")
    • Subsequence at position 220 - 222 aligns to "Y-x-G" in entry A5TYT6 (individually applies "Substrate binding")
    • Subsequence at position 271 - 271 aligns to "S" in entry A5TYT6 (individually applies "Substrate")
    • Subsequence at position 272 - 277 aligns to "[AGSQM]-[CS]-G-K-T-[NS]" in entry A5TYT6 (individually applies "GTP")
    • Subsequence at position 273 - 273 aligns to "[CS]" in entry A5TYT6 (individually applies "")
    • Subsequence at position 387 - 389 aligns to "N-x-R" in entry A5TYT6 (individually applies "Substrate binding")
    • Subsequence at position 389 - 389 aligns to "R" in entry A5TYT6 (individually applies "GTP")
    • Subsequence at position 420 - 420 aligns to "R" in entry A5TYT6 (individually applies "GTP")
    • Subsequence at position 515 - 518 aligns to "[FY]-x-x-N" in entry A5TYT6 (individually applies "GTP")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
    Short name:
    PEP carboxykinase
    Short name:
    PEPCK
    Alternative name(s):
    GTP-dependent phosphoenolpyruvate carboxykinase
    Short name:
    GTP-PEPCK

Gene namei

  • Name:pckG

Pathwayi

  • Pathwayi: gluconeogenesis

    This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.

Subcellular locationi

Catalytic activityi

  • GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.

Sequence similaritiesi

Subunit structurei

  • Monomer.

Functioni

  • Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Cofactori

  • Mn2+Note: Binds 1 Mn2+ ion per subunit.

Regioni

  • Substrate binding (to residues corresponding to positions 220 - 222)
  • Substrate binding (to residues corresponding to positions 387 - 389)

Metal bindingi

  • Manganese (to residues corresponding to position 229)
  • Manganese; via tele nitrogen (to residues corresponding to position 249)
  • Manganese (to residues corresponding to position 296)

Active sitei

  • (to residues corresponding to position 273)

Nucleotide bindingi

  • GTP (to residues corresponding to positions 272 - 277)
  • GTP (to residues corresponding to positions 515 - 518)

Binding sitei

  • Substrate (to residues corresponding to position 81)
  • Substrate (to residues corresponding to position 271)
  • GTP (to residues corresponding to position 389)
  • GTP (to residues corresponding to position 420)

Keywordsi

GO (Gene Ontology) termsi