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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 11 - 11 aligns to "K" in entry P0A763 (individually applies "ATP")
    • Subsequence at position 59 - 59 aligns to "[FY]" in entry P0A763 (individually applies "ATP")
    • Subsequence at position 87 - 87 aligns to "R" in entry P0A763 (individually applies "ATP")
    • Subsequence at position 93 - 93 aligns to "T" in entry P0A763 (individually applies "ATP")
    • Subsequence at position 104 - 104 aligns to "R" in entry P0A763 (individually applies "ATP")
    • Subsequence at position 114 - 114 aligns to "N" in entry P0A763 (individually applies "ATP")
    • Subsequence at position 117 - 117 aligns to "H" in entry P0A763 (individually applies "Pros-phosphohistidine intermediate")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Nucleoside diphosphate kinase (EC:2.7.4.6)
    Short name:
    NDK
    Short name:
    NDP kinase
    Alternative name(s):
    Nucleoside-2-P kinase

Gene namei

  • Name:ndk

Subunit structurei

  • Homotetramer.

Cofactori

Subcellular locationi

Functioni

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

Sequence similaritiesi

Catalytic activityi

  • ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Modified residuei

  • Phosphothreonine (to residues corresponding to position 92)
  • Phosphoserine (to residues corresponding to position 123)

Active sitei

  • Pros-phosphohistidine intermediate (to residues corresponding to position 117)

Binding sitei

  • ATP (to residues corresponding to position 11)
  • ATP (to residues corresponding to position 59)
  • ATP (to residues corresponding to position 87)
  • ATP (to residues corresponding to position 93)
  • ATP (to residues corresponding to position 104)
  • ATP (to residues corresponding to position 114)

Keywordsi

GO (Gene Ontology) termsi