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The annotation and conditions in this rule are derived from the following entries: P56709 (DNLI_PYRFU), Q9HHC4 (DNLI_THEKO), Q980T8 (DNLI_SULSO), Q9P9K9 (DNLI_SULSH), A2BJX6 (DNLI_HYPBU)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 247 - 247 aligns to "[DE]" in entry P56709 (individually applies "ATP")
    • Subsequence at position 249 - 249 aligns to "K" in entry P56709 (individually applies "N6-AMP-lysine intermediate")
    • Subsequence at position 254 - 254 aligns to "R" in entry P56709 (individually applies "ATP")
    • Subsequence at position 269 - 269 aligns to "R" in entry P56709 (individually applies "ATP")
    • Subsequence at position 299 - 299 aligns to "E" in entry P56709 (individually applies "ATP")
    • Subsequence at position 339 - 339 aligns to "F" in entry P56709 (individually applies "ATP")
    • Subsequence at position 414 - 414 aligns to "R" in entry P56709 (individually applies "ATP")
    • Subsequence at position 420 - 420 aligns to "K" in entry P56709 (individually applies "ATP")

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Probable DNA ligase (EC:6.5.1.1)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]
  • Recommended name:
    DNA ligase (EC:6.5.1.6)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP/NAD(+)]
  • Recommended name:
    DNA ligase (EC:6.5.1.1)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]

Gene namei

  • Name:lig

Cofactori

Sequence similaritiesi

Functioni

  • DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Catalytic activityi

  • ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.
  • NAD+ + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + beta-nicotinamide D-nucleotide.

Binding sitei

  • ATP (to residues corresponding to position 247)
  • ATP (to residues corresponding to position 254)
  • ATP (to residues corresponding to position 269)
  • ATP (to residues corresponding to position 299)
  • ATP (to residues corresponding to position 339)
  • ATP (to residues corresponding to position 414)
  • ATP (to residues corresponding to position 420)

Active sitei

  • N6-AMP-lysine intermediate (to residues corresponding to position 249)

Keywordsi

GO (Gene Ontology) termsi

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