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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 62 - 62 aligns to "D" in entry Q8ZQ06 (individually applies "Substrate")
    • Subsequence at position 70 - 70 aligns to "R" in entry Q8ZQ06 (individually applies "Substrate")
    • Subsequence at position 133 - 133 aligns to "R" in entry Q8ZQ06 (individually applies "Substrate")
    • Subsequence at position 163 - 164 aligns to "K-H" in entry Q8ZQ06 (individually applies "Substrate binding")
    • Subsequence at position 174 - 174 aligns to "D" in entry Q8ZQ06 (individually applies "Important for catalytic activity")
    • Subsequence at position 176 - 176 aligns to "H" in entry Q8ZQ06 (individually applies "Proton donor/acceptor")
    • Subsequence at position 248 - 248 aligns to "D" in entry Q8ZQ06 (individually applies "Nucleophile")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Beta-hexosaminidase (EC:3.2.1.52)
    Alternative name(s):
    Beta-N-acetylhexosaminidase
    N-acetyl-beta-glucosaminidase

Gene namei

  • Name:nagZ

Pathwayi

  • Pathwayi: peptidoglycan recycling

    This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.

Subcellular locationi

Functioni

  • Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

Sequence similaritiesi

Catalytic activityi

  • Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Regioni

  • Substrate binding (to residues corresponding to positions 163 - 164)

Active sitei

  • Proton donor/acceptor (to residues corresponding to position 176)
  • Nucleophile (to residues corresponding to position 248)

Sitei

  • Important for catalytic activity (to residues corresponding to position 174)

Binding sitei

  • Substrate (to residues corresponding to position 62)
  • Substrate (to residues corresponding to position 70)
  • Substrate (to residues corresponding to position 133)

Keywordsi

GO (Gene Ontology) termsi