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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 62 - 62 aligns to "D" in entry Q8ZQ06 (individually applies "Substrate")
    • Subsequence at position 70 - 70 aligns to "R" in entry Q8ZQ06 (individually applies "Substrate")
    • Subsequence at position 133 - 133 aligns to "R" in entry Q8ZQ06 (individually applies "Substrate")
    • Subsequence at position 163 - 164 aligns to "K-H" in entry Q8ZQ06 (individually applies "Substrate binding")
    • Subsequence at position 174 - 174 aligns to "D" in entry Q8ZQ06 (individually applies "Important for catalytic activity")
    • Subsequence at position 176 - 176 aligns to "H" in entry Q8ZQ06 (individually applies "Proton donor/acceptor")
    • Subsequence at position 248 - 248 aligns to "D" in entry Q8ZQ06 (individually applies "Nucleophile")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Beta-hexosaminidase (EC:3.2.1.52)
    Alternative name(s):
    N-acetyl-beta-glucosaminidase
    Beta-N-acetylhexosaminidase

Gene namei

  • Name:nagZ

Functioni

  • Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

Pathwayi

  • Pathwayi: peptidoglycan recycling

    This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.
    View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Catalytic activityi

  • Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Subcellular locationi

Sequence similaritiesi

Binding sitei

  • Substrate (to residues corresponding to position 62)
  • Substrate (to residues corresponding to position 70)
  • Substrate (to residues corresponding to position 133)

Active sitei

  • Proton donor/acceptor (to residues corresponding to position 176)
  • Nucleophile (to residues corresponding to position 248)

Sitei

  • Important for catalytic activity (to residues corresponding to position 174)

Regioni

  • Substrate binding (to residues corresponding to positions 163 - 164)

Keywordsi

GO (Gene Ontology) termsi