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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01660
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

... then these annotations are applied i

Protein namesi

  • Recommended name:
    2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC:4.2.99.20)
    Short name:
    SHCHC synthase
  • Recommended name:
    Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC:4.2.99.20)
    Short name:
    SHCHC synthase

Gene namei

  • Name:menH

Catalytic activityi

  • 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.

Sequence similaritiesi

Functioni

  • Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).

Pathwayi

  • Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

    This protein is involved in step 3 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate. This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
  • Pathwayi: phylloquinone biosynthesis

    This protein is involved in the pathway phylloquinone biosynthesis, which is part of Cofactor biosynthesis.
  • Pathwayi: menaquinone biosynthesis

    This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.

Subunit structurei

  • Monomer.

Keywordsi

GO (Gene Ontology) termsi

  • GO:0070205 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
  • GO:0042372 phylloquinone biosynthetic process
  • GO:0009234 menaquinone biosynthetic process