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The annotation and conditions in this rule are derived from the following entries: Q58018 (THI4_METJA), P32318 (THI4_YEAST)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 47 - 47 does not align to "S" in entry Q58018
    • Subsequence at position 47 - 47 aligns to "A" in entry Q58018
    • Subsequence at position 164 - 166 aligns to "H-x-D" in entry Q58018
    • Subsequence at position 164 - 166 does not align to "H-x-D" in entry Q58018
    • Subsequence at position 166 - 166 aligns to "D" in entry Q58018
    • Subsequence at position 66 - 67 aligns to "E-[RKQE]" in entry Q58018 (individually applies "NAD")
    • Subsequence at position 74 - 74 aligns to "G" in entry Q58018 (individually applies "NAD; via amide nitrogen and carbonyl oxygen")
    • Subsequence at position 138 - 138 aligns to "[VIL]" in entry Q58018 (individually applies "NAD; via amide nitrogen and carbonyl oxygen")
    • Subsequence at position 166 - 166 aligns to "D" in entry Q58018 (individually applies "Iron; shared with adjacent protomer")
    • Subsequence at position 181 - 181 aligns to "H" in entry Q58018 (individually applies "Iron")
    • Subsequence at position 184 - 184 aligns to "S" in entry Q58018 (individually applies "NAD; via carbonyl oxygen")
    • Subsequence at position 230 - 230 aligns to "[MLI]" in entry Q58018 (individually applies "NAD; via amide nitrogen")
    • Subsequence at position 240 - 240 aligns to "R" in entry Q58018 (individually applies "Glycine")
    • Subsequence at position 47 - 47 aligns to "S" in entry Q58018

... then these annotations are applied i

Protein namei

  • Recommended name:
    Thiamine thiazole synthase (EC:4.-.-.-)

Gene namei

  • Name:thi4

Pathwayi

  • Pathwayi: thiamine diphosphate biosynthesis

    This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Subunit structurei

  • Homooctamer; tetramer of dimers.

Sequence similaritiesi

Cofactori

Functioni

  • Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

Nucleotide bindingi

  • NAD; shared with adjacent protomer (to residues corresponding to positions 164 - 166)
  • NAD (to residues corresponding to positions 66 - 67)

Metal bindingi

  • Iron; shared with adjacent protomer (to residues corresponding to position 166)
  • Iron (to residues corresponding to position 181)

Binding sitei

  • NAD; via amide nitrogen (to residues corresponding to position 47)
  • NAD; shared with adjacent protomer (to residues corresponding to position 166)
  • NAD; via amide nitrogen and carbonyl oxygen (to residues corresponding to position 74)
  • NAD; via amide nitrogen and carbonyl oxygen (to residues corresponding to position 138)
  • NAD; via carbonyl oxygen (to residues corresponding to position 184)
  • NAD; via amide nitrogen (to residues corresponding to position 230)
  • Glycine (to residues corresponding to position 240)
  • NAD (to residues corresponding to position 47)

Keywordsi

GO (Gene Ontology) termsi

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