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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01657
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 12 - 15 aligns to "[ST]-G-[NDAVS]-[IV]" in entry Q52060 (individually applies "NAD")
    • Subsequence at position 132 - 132 aligns to "C" in entry Q52060 (individually applies "Acyl-thioester intermediate")
    • Subsequence at position 163 - 171 aligns to "[SG]-x-G-[PI]-[GA]-[TS]-x-x-N" in entry Q52060 (individually applies "NAD")
    • Subsequence at position 290 - 290 aligns to "N" in entry Q52060 (individually applies "NAD")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Acetaldehyde dehydrogenase (EC:1.2.1.10)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]

Gene namei

  • Name:mhpF

Subunit structurei

  • Interacts with MhpE.

Pathwayi

  • Pathwayi: 3-phenylpropanoate degradation

    This protein is involved in the pathway 3-phenylpropanoate degradation, which is part of Aromatic compound metabolism.

Functioni

  • Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.

Sequence similaritiesi

Catalytic activityi

  • Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.

Active sitei

  • Acyl-thioester intermediate (to residues corresponding to position 132)

Nucleotide bindingi

  • NAD (to residues corresponding to positions 12 - 15)
  • NAD (to residues corresponding to positions 163 - 171)

Binding sitei

  • NAD (to residues corresponding to position 290)

Keywordsi

GO (Gene Ontology) termsi