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The annotation and conditions in this rule are derived from the following entries: P77671 (ALLB_ECOLI), O32137 (ALLB_BACSU)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01645
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 59 - 59 aligns to "H" in entry P77671 (individually applies "Zinc 1")
    • Subsequence at position 61 - 61 aligns to "H" in entry P77671 (individually applies "Zinc 1")
    • Subsequence at position 146 - 146 aligns to "K" in entry P77671 (individually applies "Zinc 1; via carbamate group")
    • Subsequence at position 146 - 146 aligns to "K" in entry P77671 (individually applies "Zinc 2; via carbamate group")
    • Subsequence at position 146 - 146 aligns to "K" in entry P77671 (individually applies "N6-carboxylysine")
    • Subsequence at position 186 - 186 aligns to "H" in entry P77671 (individually applies "Zinc 2")
    • Subsequence at position 242 - 242 aligns to "H" in entry P77671 (individually applies "Zinc 2")
    • Subsequence at position 315 - 315 aligns to "D" in entry P77671 (individually applies "Zinc 1")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Allantoinase (EC:3.5.2.5)
    Alternative name(s):
    Allantoin-utilizing enzyme

Gene namesi

  • Name:allB, Synonym:pucH
  • Name:allB

Sequence similaritiesi

Catalytic activityi

  • (S)-allantoin + H2O = allantoate.

Cofactori

  • Zn2+Note: Binds 2 Zn2+ ions per subunit.

Post-translational modificationi

  • Carbamylation allows a single lysine to coordinate two zinc ions.

Subunit structurei

  • Homotetramer.

Functioni

  • Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.

Pathwayi

  • Pathwayi: (S)-allantoin degradation

    This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin. This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Modified residuei

  • N6-carboxylysine (to residues corresponding to position 146)

Metal bindingi

  • Zinc 1 (to residues corresponding to position 59)
  • Zinc 1 (to residues corresponding to position 61)
  • Zinc 1; via carbamate group (to residues corresponding to position 146)
  • Zinc 2; via carbamate group (to residues corresponding to position 146)
  • Zinc 2 (to residues corresponding to position 186)
  • Zinc 2 (to residues corresponding to position 242)
  • Zinc 1 (to residues corresponding to position 315)

Keywordsi

GO (Gene Ontology) termsi

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