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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 45 - 45 aligns to "M" in entry P39593 (individually applies "Substrate; via amide nitrogen")
    • Subsequence at position 121 - 121 aligns to entry P39593 (individually applies "ATP")
    • Subsequence at position 168 - 168 aligns to "[ST]" in entry P39593 (individually applies "ATP")
    • Subsequence at position 195 - 195 aligns to "[GA]" in entry P39593 (individually applies "Substrate; via amide nitrogen")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Hydroxyethylthiazole kinase (EC:2.7.1.50)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinase
    Short name:
    TH kinase
    Short name:
    Thz kinase

Gene namei

  • Name:thiM

Sequence similaritiesi

Pathwayi

  • Pathwayi: thiamine diphosphate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole. This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole, the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Catalytic activityi

  • ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.

Functioni

  • Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

Cofactori

Binding sitei

  • Substrate; via amide nitrogen (to residues corresponding to position 45)
  • ATP (to residues corresponding to position 121)
  • ATP (to residues corresponding to position 168)
  • Substrate; via amide nitrogen (to residues corresponding to position 195)

Keywordsi

GO (Gene Ontology) termsi