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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 45 - 45 aligns to "M" in entry P39593 (individually applies "Substrate; via amide nitrogen")
    • Subsequence at position 121 - 121 aligns to entry P39593 (individually applies "ATP")
    • Subsequence at position 168 - 168 aligns to "[ST]" in entry P39593 (individually applies "ATP")
    • Subsequence at position 195 - 195 aligns to "[GA]" in entry P39593 (individually applies "Substrate; via amide nitrogen")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Hydroxyethylthiazole kinase (EC:2.7.1.50)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinase
    Short name:
    TH kinase
    Short name:
    Thz kinase

Gene namei

  • Name:thiM

Pathwayi

  • Pathwayi: thiamine diphosphate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole. This subpathway is part of the pathway thiamine diphosphate biosynthesis, which is itself part of Cofactor biosynthesis.

Cofactori

Sequence similaritiesi

Catalytic activityi

  • ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.

Functioni

  • Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

Binding sitei

  • Substrate; via amide nitrogen (to residues corresponding to position 45)
  • ATP (to residues corresponding to position 121)
  • ATP (to residues corresponding to position 168)
  • Substrate; via amide nitrogen (to residues corresponding to position 195)

Keywordsi

GO (Gene Ontology) termsi