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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 11 - 11 aligns to "N" in entry P44859 (individually applies "Substrate")
    • Subsequence at position 44 - 44 aligns to "Q" in entry P44859 (individually applies "Substrate")
    • Subsequence at position 64 - 64 aligns to "[NQ]" in entry P44859 (individually applies "Substrate")
    • Subsequence at position 73 - 73 aligns to "C" in entry P44859 (individually applies "Proton donor")
    • Subsequence at position 74 - 75 aligns to "[GI]-N" in entry P44859 (individually applies "Substrate binding")
    • Subsequence at position 157 - 157 aligns to "N" in entry P44859 (individually applies "Substrate")
    • Subsequence at position 159 - 159 aligns to "H" in entry P44859 (individually applies "Could be important to modulate the pK values of the two catalytic cysteine residues")
    • Subsequence at position 190 - 190 aligns to "N" in entry P44859 (individually applies "Substrate")
    • Subsequence at position 208 - 208 aligns to "E" in entry P44859 (individually applies "Could be important to modulate the pK values of the two catalytic cysteine residues")
    • Subsequence at position 208 - 209 aligns to "E-R" in entry P44859 (individually applies "Substrate binding")
    • Subsequence at position 217 - 217 aligns to "C" in entry P44859 (individually applies "Proton acceptor")
    • Subsequence at position 218 - 219 aligns to "G-[ST]" in entry P44859 (individually applies "Substrate binding")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Diaminopimelate epimerase (EC:5.1.1.7)
    Short name:
    DAP epimerase
    Alternative name(s):
    PLP-independent amino acid racemase

Gene namei

  • Name:dapF

Subunit structurei

  • Homodimer.

Pathwayi

  • Pathwayi: L-lysine biosynthesis via DAP pathway

    This protein is involved in step 1 of the subpathway that synthesizes DL-2,6-diaminopimelate from LL-2,6-diaminopimelate. This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.

Functioni

  • Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
  • Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.

Subcellular locationi

Sequence similaritiesi

Catalytic activityi

  • LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.

Regioni

  • Substrate binding (to residues corresponding to positions 74 - 75)
  • Substrate binding (to residues corresponding to positions 208 - 209)
  • Substrate binding (to residues corresponding to positions 218 - 219)

Active sitei

  • Proton donor (to residues corresponding to position 73)
  • Proton acceptor (to residues corresponding to position 217)

Sitei

  • Could be important to modulate the pK values of the two catalytic cysteine residues (to residues corresponding to position 159)
  • Could be important to modulate the pK values of the two catalytic cysteine residues (to residues corresponding to position 208)
  • Important for dimerization (to residues corresponding to position 268)

Binding sitei

  • Substrate (to residues corresponding to position 11)
  • Substrate (to residues corresponding to position 44)
  • Substrate (to residues corresponding to position 64)
  • Substrate (to residues corresponding to position 157)
  • Substrate (to residues corresponding to position 190)

Keywordsi

GO (Gene Ontology) termsi