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The annotation and conditions in this rule are derived from the following entries: P17169 (GLMS_ECOLI), Q56213 (GLMS_THET8), Q6LWM9 (GLMS_METMP)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00164
    • gene location = Plastid
    • fragment ≠ the sequence is fragmented

Special conditions

    • gene location = Plastid; Chloroplast
    • gene location ≠ Plastid; Chloroplast
    • Subsequence at position 1 - 1 aligns to "M" in entry P17169 (individually applies "Removed")
    • Subsequence at position 2 - 2 aligns to "C" in entry P17169 (individually applies "Nucleophile; for GATase activity")
    • Subsequence at position 604 - 604 aligns to "K" in entry P17169 (individually applies "For Fru-6P isomerization activity")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:
    Alternative name(s):
    L-glutamine--D-fructose-6-phosphate amidotransferase
    Glucosamine-6-phosphate synthase
    Hexosephosphate aminotransferase
    D-fructose-6-phosphate amidotransferase

Gene namei

  • Name:glmS


  • Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.

Catalytic activityi

  • L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

Subcellular locationi

Subunit structurei

  • Homodimer.

Active sitei

  • Nucleophile; for GATase activity (to residues corresponding to position 2)
  • For Fru-6P isomerization activity (to residues corresponding to position 604)

Initiator methioninei

  • Removed (to residues corresponding to position 1)


GO (Gene Ontology) termsi