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If a protein meets these conditions... i

Common conditions

Special conditions

    • proteome property = Membrane=2
    • proteome property = Membrane=1
    • proteome property ≠ Membrane=*
    • Subsequence at position 24 - 24 aligns to "Y" in entry P33232 (individually applies "Substrate")
    • Subsequence at position 106 - 106 aligns to "S" in entry P33232 (individually applies "FMN")
    • Subsequence at position 127 - 127 aligns to "Q" in entry P33232 (individually applies "FMN")
    • Subsequence at position 129 - 129 aligns to "Y" in entry P33232 (individually applies "Substrate")
    • Subsequence at position 155 - 155 aligns to "T" in entry P33232 (individually applies "FMN")
    • Subsequence at position 164 - 164 aligns to "R" in entry P33232 (individually applies "Substrate")
    • Subsequence at position 251 - 251 aligns to "K" in entry P33232 (individually applies "FMN")
    • Subsequence at position 275 - 275 aligns to "H" in entry P33232 (individually applies "Proton acceptor")
    • Subsequence at position 278 - 278 aligns to "R" in entry P33232 (individually applies "Substrate")
    • Subsequence at position 306 - 330 aligns to entry P33232 (individually applies "FMN")

... then these annotations are applied i

Protein namei

  • Recommended name:
    L-lactate dehydrogenase (EC:1.1.-.-)

Gene namei

  • Name:lldD

Subcellular locationi

Functioni

  • Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.

Subunit structurei

  • Homotetramer.

Catalytic activityi

  • (S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.

Cofactori

Sequence similaritiesi

Nucleotide bindingi

  • FMN (to residues corresponding to positions 306 - 330)

Active sitei

  • Proton acceptor (to residues corresponding to position 275)

Binding sitei

  • Substrate (to residues corresponding to position 24)
  • FMN (to residues corresponding to position 106)
  • FMN (to residues corresponding to position 127)
  • Substrate (to residues corresponding to position 129)
  • FMN (to residues corresponding to position 155)
  • Substrate (to residues corresponding to position 164)
  • FMN (to residues corresponding to position 251)
  • Substrate (to residues corresponding to position 278)

Keywordsi

GO (Gene Ontology) termsi