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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00139
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Bifunctional purine biosynthesis protein PurH

Cleaved chain(s) or included domain(s)i

  • Includes domain:
    Recommended name:
    Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
    Alternative name(s):
    AICAR transformylase
  • Includes domain:
    Recommended name:
    IMP cyclohydrolase (EC:3.5.4.10)
    Alternative name(s):
    Inosinicase
    IMP synthase
    ATIC

Gene namei

  • Name:purH

Pathwayi

  • Pathwayi: IMP biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route). This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
  • Pathwayi: IMP biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.

Domaini

  • The IMP cyclohydrolase activity resides in the N-terminal region.

Sequence similaritiesi

Catalytic activityi

  • 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
  • IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Modified residuei

  • N6-acetyllysine (to residues corresponding to position 287)

Keywordsi

GO (Gene Ontology) termsi

  • GO:0003937 IMP cyclohydrolase activity
  • GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity
  • GO:0006189 'de novo' IMP biosynthetic process