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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00139
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Bifunctional purine biosynthesis protein PurH

Cleaved chain(s) or included domain(s)i

  • Includes domain:
    Recommended name:
    IMP cyclohydrolase (EC:3.5.4.10)
    Alternative name(s):
    ATIC
    Inosinicase
    IMP synthase
  • Includes domain:
    Recommended name:
    Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
    Alternative name(s):
    AICAR transformylase

Gene namei

  • Name:purH

Catalytic activityi

  • 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
  • IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

  • Pathwayi: IMP biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route). This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.
  • Pathwayi: IMP biosynthesis via de novo pathway

    This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Domaini

  • The IMP cyclohydrolase activity resides in the N-terminal region.

Sequence similaritiesi

Modified residuei

  • N6-acetyllysine (to residues corresponding to position 287)

Keywordsi

GO (Gene Ontology) termsi

  • GO:0003937 IMP cyclohydrolase activity
  • GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity
  • GO:0006189 'de novo' IMP biosynthetic process