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The annotation and conditions in this rule are derived from the following entries: P18912 (PGK_GEOSE), Q8GIZ5 (PGK_LACDL), P36204 (PGKT_THEMA), P09403 (PGK_THET8), P61884 (PGK_PYRWO)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 21 - 23 aligns to "D-[LFMYVI]-N" in entry P36204 (individually applies "Substrate binding")
    • Subsequence at position 36 - 36 aligns to "R" in entry P36204 (individually applies "Substrate")
    • Subsequence at position 59 - 62 aligns to "[HQR]-x-[GSDRK]-[RGKNDP]" in entry P36204 (individually applies "Substrate binding")
    • Subsequence at position 118 - 118 aligns to "R" in entry P36204 (individually applies "Substrate")
    • Subsequence at position 151 - 151 aligns to "R" in entry P36204 (individually applies "Substrate")
    • Subsequence at position 201 - 201 aligns to "K" in entry P36204 (individually applies "ATP")
    • Subsequence at position 293 - 293 aligns to "G" in entry P36204 (individually applies "ATP; via carbonyl oxygen")
    • Subsequence at position 324 - 324 aligns to "E" in entry P36204 (individually applies "ATP")
    • Subsequence at position 353 - 356 aligns to "G-G-[DEH]-[STAILFM]" in entry P36204 (individually applies "ATP")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)

Gene namei

  • Name:pgk

Subunit structurei

  • Monomer.

Subcellular locationi

Sequence similaritiesi

Pathwayi

  • Pathwayi: glycolysis

    This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate. This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Catalytic activityi

  • ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Nucleotide bindingi

  • ATP (to residues corresponding to positions 353 - 356)

Modified residuei

  • Phosphoserine (to residues corresponding to position 183)
  • Phosphothreonine (to residues corresponding to position 299)
  • N6-acetyllysine (to residues corresponding to position 84)

Binding sitei

  • Substrate (to residues corresponding to position 36)
  • Substrate (to residues corresponding to position 118)
  • Substrate (to residues corresponding to position 151)
  • ATP (to residues corresponding to position 201)
  • ATP; via carbonyl oxygen (to residues corresponding to position 293)
  • ATP (to residues corresponding to position 324)

Regioni

  • Substrate binding (to residues corresponding to positions 21 - 23)
  • Substrate binding (to residues corresponding to positions 59 - 62)

Keywordsi

GO (Gene Ontology) termsi

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