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The annotation and conditions in this rule are derived from the following entries: Q58185 (MPTA_METJA), P94398 (GCH4_BACSU), Q5F9K6 (GCH4_NEIG1), Q9WXP6 (GCH4_THEMA)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_01527_A
    • taxon = Archaea
    • fragment ≠ the sequence is fragmented

Special conditions

... then these annotations are applied i

Protein namesi

  • Recommended name:
    GTP cyclohydrolase MptA (EC:3.5.4.39)
    Alternative name(s):
    GTP cyclohydrolase IV
  • Recommended name:
    GTP cyclohydrolase FolE2 (EC:3.5.4.16)

Gene namesi

  • Name:mptA
  • Name:folE2

Catalytic activityi

  • GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.
  • GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Functioni

  • Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
  • Converts GTP to 7,8-dihydroneopterin triphosphate.

Cofactori

  • Fe2+Note: Binds 1 Fe2+ ion per subunit.

Sequence similaritiesi

Subunit structurei

  • Homodimer.

Pathwayi

  • Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

    This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.
  • Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP. This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sitei

  • May be catalytically important (to residues corresponding to position 160)
  • May be catalytically important (to residues corresponding to position 183)

Keywordsi

GO (Gene Ontology) termsi

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