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The annotation and conditions in this rule are derived from the following entries: P23492 (PNPH_MOUSE), P00491 (PNPH_HUMAN), P45563 (XAPA_ECOLI)

If a protein meets these conditions... i

Common conditions

Special conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Purine nucleoside phosphorylase (EC:
    Alternative name(s):
    Inosine-guanosine phosphorylase

Catalytic activityi

  • Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
  • Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.


  • The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

Sequence similaritiesi


  • Pathwayi: purine nucleoside salvage

    This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.