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The annotation and conditions in this rule are derived from the following entries: P96112 (SURE_THEMA), P0A840 (SURE_ECOLI), Q8ZU79 (SURE1_PYRAE)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 8 - 8 aligns to "D" in entry P96112 (individually applies "Divalent metal cation")
    • Subsequence at position 9 - 9 aligns to "D" in entry P96112 (individually applies "Divalent metal cation")
    • Subsequence at position 39 - 39 aligns to "S" in entry P96112 (individually applies "Divalent metal cation")
    • Subsequence at position 95 - 95 aligns to "N" in entry P96112 (individually applies "Divalent metal cation")

... then these annotations are applied i

Protein namesi

  • Recommended name:
    5'/3'-nucleotidase SurE (EC:3.1.3.5, EC:3.1.3.6)
    Alternative name(s):
    Nucleoside monophosphate phosphohydrolase
    Exopolyphosphatase (EC:3.6.1.11)
  • Recommended name:
    5'-nucleotidase SurE (EC:3.1.3.5)
    Alternative name(s):
    Nucleoside 5'-monophosphate phosphohydrolase

Gene namei

  • Name:surE

Catalytic activityi

  • (Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.
  • A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.
  • A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
  • A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Subcellular locationi

Sequence similaritiesi

Functioni

  • Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
  • Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

Cofactori

Metal bindingi

  • Divalent metal cation (to residues corresponding to position 8)
  • Divalent metal cation (to residues corresponding to position 9)
  • Divalent metal cation (to residues corresponding to position 39)
  • Divalent metal cation (to residues corresponding to position 95)

Keywordsi

GO (Gene Ontology) termsi

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