Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

The annotation and conditions in this rule are derived from the following entries: P07813 (SYL_ECOLI)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00049_A
    • taxon = Archaea
    • fragment ≠ the sequence is fragmented

Special conditions

    • taxon = Bacteria
    • Subsequence at position 42 - 52 aligns to "[SP]-[YF]-[PLVT]-[SN]-[GAS]-x(1,3)-H-[LIVMA]-G-[HS]" in entry P07813 (individually applies ""HIGH" region")
    • Subsequence at position 619 - 623 aligns to "[KRTA]-[MLI]-[SGA]-[KS]-[SA]" in entry P07813 (individually applies ""KMSKS" region")
    • Subsequence at position 622 - 622 aligns to "K" in entry P07813 (individually applies "ATP")
    • taxon = Archaea
    • Subsequence at position 41 - 51 aligns to "P-Y-x-[SN]-[GAS]-x(2)-H-[LIVMA]-G-[HS]" in entry Q58050 (individually applies ""HIGH" region")
    • Subsequence at position 633 - 637 aligns to entry Q58050 (individually applies ""KMSKS" region")
    • Subsequence at position 636 - 636 aligns to "K" in entry Q58050 (individually applies "ATP")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Leucine--tRNA ligase (EC:6.1.1.4)
    Alternative name(s):
    Leucyl-tRNA synthetase
    Short name:
    LeuRS

Gene namei

  • Name:leuS

Sequence similaritiesi

Catalytic activityi

  • ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Subcellular locationi

Binding sitei

  • ATP (to residues corresponding to position 622)
  • ATP (to residues corresponding to position 636)

Motifi

  • "HIGH" region (to residues corresponding to positions 42 - 52)
  • "KMSKS" region (to residues corresponding to positions 619 - 623)
  • "HIGH" region (to residues corresponding to positions 41 - 51)
  • "KMSKS" region (to residues corresponding to positions 633 - 637)

Keywordsi

GO (Gene Ontology) termsi