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The annotation and conditions in this rule are derived from the following entries: P0A7Y4 (RNH_ECOLI), P29253 (RNH_THET8)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00042
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 10 - 10 aligns to "D" in entry P0A7Y4 (individually applies "Magnesium 1")
    • Subsequence at position 10 - 10 aligns to "D" in entry P0A7Y4 (individually applies "Magnesium 2")
    • Subsequence at position 48 - 48 aligns to "E" in entry P0A7Y4 (individually applies "Magnesium 1")
    • Subsequence at position 70 - 70 aligns to "D" in entry P0A7Y4 (individually applies "Magnesium 1")
    • Subsequence at position 134 - 134 aligns to "D" in entry P0A7Y4 (individually applies "Magnesium 2")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Ribonuclease H (EC:3.1.26.4)
    Short name:
    RNase H

Gene namei

  • Name:rnhA

Subunit structurei

  • Monomer.

Functioni

  • Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Catalytic activityi

  • Endonucleolytic cleavage to 5'-phosphomonoester.

Subcellular locationi

Cofactori

  • Mg2+Note: Binds 1 Mg2+ ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.

Sequence similaritiesi

Metal bindingi

  • Magnesium 1 (to residues corresponding to position 10)
  • Magnesium 2 (to residues corresponding to position 10)
  • Magnesium 1 (to residues corresponding to position 48)
  • Magnesium 1 (to residues corresponding to position 70)
  • Magnesium 2 (to residues corresponding to position 134)

Keywordsi

GO (Gene Ontology) termsi