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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00015
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • Subsequence at position 28 - 48 aligns to entry P0A7C2 (individually applies "H-T-H motif")
    • Subsequence at position 84 - 85 aligns to "A-G" in entry P0A7C2 (individually applies "Cleavage; by autolysis")
    • Subsequence at position 119 - 119 aligns to "S" in entry P0A7C2 (individually applies "For autocatalytic cleavage activity")
    • Subsequence at position 156 - 156 aligns to "K" in entry P0A7C2 (individually applies "For autocatalytic cleavage activity")

... then these annotations are applied i

Protein namei

  • Recommended name:
    LexA repressor (EC:3.4.21.88)

Gene namei

  • Name:lexA

Subunit structurei

  • Homodimer.

Functioni

  • Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  • Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

Catalytic activityi

  • Hydrolysis of Ala-|-Gly bond in repressor LexA.

Sequence similaritiesi

Active sitei

  • For autocatalytic cleavage activity (to residues corresponding to position 119)
  • For autocatalytic cleavage activity (to residues corresponding to position 156)

Sitei

  • Cleavage; by autolysis (to residues corresponding to positions 84 - 85)

DNA bindingi

  • H-T-H motif (to residues corresponding to positions 28 - 48)

Keywordsi

GO (Gene Ontology) termsi