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The annotation and conditions in this rule are derived from the following entries: P60932 (UPPP_ECOLI), P60934 (UPPP_STRPN)

If a protein meets these conditions... i

Common conditions

Special conditions

    • proteome property = Membrane=2
    • proteome property = Membrane=1
    • proteome property ≠ Membrane=*
    • Predicted transmembrane

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Undecaprenyl-diphosphatase (EC:3.6.1.27)
    Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase
  • Recommended name:
    Undecaprenyl-diphosphatase (EC:3.6.1.27)
    Alternative name(s):
    Bacitracin resistance protein
    Undecaprenyl pyrophosphate phosphatase

Gene namei

  • Name:uppP

Functioni

  • Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
  • Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.

Miscellaneousi

  • Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

  • Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

Subcellular locationi

Sequence similaritiesi

Transmembranei

  • Helical (to residues corresponding to positions @FROM@i - @TO@i)

Keywordsi

GO (Gene Ontology) termsi