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The annotation and conditions in this rule are derived from the following entries: P0A7B5 (PROB_ECOLI), P17856 (PROB_SERMA), P96488 (PROB_STRTR)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 10 - 10 aligns to "K" in entry P0A7B5 (individually applies "ATP")
    • Subsequence at position 50 - 50 aligns to "S" in entry P0A7B5 (individually applies "Substrate")
    • Subsequence at position 137 - 137 aligns to "D" in entry P0A7B5 (individually applies "Substrate")
    • Subsequence at position 149 - 149 aligns to "N" in entry P0A7B5 (individually applies "Substrate; via amide nitrogen")
    • Subsequence at position 169 - 170 aligns to "[TS]-D" in entry P0A7B5 (individually applies "ATP")
    • Subsequence at position 211 - 217 aligns to "[TS]-G-G-[MI]-x-[TS]-K" in entry P0A7B5 (individually applies "ATP")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Glutamate 5-kinase (EC:2.7.2.11)
    Alternative name(s):
    Gamma-glutamyl kinase
    Short name:
    GK

Gene namei

  • Name:proB

Subcellular locationi

Sequence similaritiesi

Functioni

  • Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.

Catalytic activityi

  • ATP + L-glutamate = ADP + L-glutamate 5-phosphate.

Pathwayi

  • Pathwayi: L-proline biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate. This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

Binding sitei

  • ATP (to residues corresponding to position 10)
  • Substrate (to residues corresponding to position 50)
  • Substrate (to residues corresponding to position 137)
  • Substrate; via amide nitrogen (to residues corresponding to position 149)

Nucleotide bindingi

  • ATP (to residues corresponding to positions 169 - 170)
  • ATP (to residues corresponding to positions 211 - 217)

Keywordsi

GO (Gene Ontology) termsi