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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00057
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

... then these annotations are applied i

Protein namesi

  • Recommended name:
    8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase (EC:
    Alternative name(s):
    CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase
  • Recommended name:
    3-deoxy-manno-octulosonate cytidylyltransferase (EC:
    Alternative name(s):
    CMP-2-keto-3-deoxyoctulosonic acid synthase
    Short name:
    Short name:
    CMP-KDO synthase

Gene namei

  • Name:kdsB

Catalytic activityi

  • CTP + 8-amino-3,8-dideoxy-alpha-D-manno-octulosonate = diphosphate + CMP-8-amino-3,8-dideoxy-alpha-D-manno-octulosonate.
  • CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.

Sequence similaritiesi


  • Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus.
  • Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.


  • Pathwayi: CMP-3-deoxy-D-manno-octulosonate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP. This subpathway is part of the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
  • Pathwayi: lipopolysaccharide biosynthesis

    This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.