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The annotation and conditions in this rule are derived from the following entries: P17443 (MURG_ECOLI)

If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00033
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

Special conditions

    • proteome property = Membrane=2
    • proteome property = Membrane=1
    • proteome property ≠ Membrane=*

... then these annotations are applied i

Protein namei

  • Recommended name:
    UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC:2.4.1.227)
    Alternative name(s):
    Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase

Gene namei

  • Name:murG

Sequence similaritiesi

Functioni

  • Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

Subcellular locationi

Catalytic activityi

  • UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

Pathwayi

  • Pathwayi: peptidoglycan biosynthesis

    This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
    View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Keywordsi

GO (Gene Ontology) termsi

  • GO:0005886 plasma membrane
  • GO:0009252 peptidoglycan biosynthetic process
  • GO:0030259 lipid glycosylation
  • GO:0050511 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity

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