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If a protein meets these conditions... i

Common conditions

    • Matches HAMAP signature MF_00227
    • taxon = Bacteria
    • fragment ≠ the sequence is fragmented

... then these annotations are applied i

Protein namei

  • Recommended name:
    Ribonuclease P protein component (EC:
    Short name:
    RNase P protein
    Short name:
    RNaseP protein
    Alternative name(s):
    Protein C5

Gene namei

  • Name:rnpA

Catalytic activityi

  • Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.


  • RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

Subunit structurei

  • Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.

Sequence similaritiesi


GO (Gene Ontology) termsi