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If a protein meets these conditions... i

Common conditions

Special conditions

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Proteasome subunit alpha (EC:3.4.25.1)
    Alternative name(s):
    20S proteasome alpha subunit
    Proteasome core protein PsmA
  • Recommended name:
    Proteasome subunit alpha (EC:3.4.25.1)
    Alternative name(s):
    20S proteasome alpha subunit
    Proteasome core protein PrcA

Gene namesi

  • Name:psmA
  • Name:prcA

Catalytic activityi

  • Cleavage of peptide bonds with very broad specificity.

Sequence similaritiesi

Subcellular locationi

Functioni

  • Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.

Enzyme regulationi

  • The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.
  • The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

Subunit structurei

  • The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
  • The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.

Pathwayi

  • Pathwayi: proteasomal Pup-dependent pathway

    This protein is involved in the pathway proteasomal Pup-dependent pathway, which is part of Protein degradation.
    View all proteins of this organism that are known to be involved in the pathway proteasomal Pup-dependent pathway and in Protein degradation.

Keywordsi

GO (Gene Ontology) termsi