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The annotation and conditions in this rule are derived from the following entries: P31113 (MENG_BACSU), P0A887 (UBIE_ECOLI), P49017 (COQ5_YEAST)

If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 122 - 122 aligns to "[ST]" in entry P49017 (individually applies "S-adenosyl-L-methionine")
    • Subsequence at position 148 - 148 aligns to "D" in entry P49017 (individually applies "S-adenosyl-L-methionine")
    • Subsequence at position 179 - 180 aligns to "[ND]-x" in entry P49017 (individually applies "S-adenosyl-L-methionine binding")
    • Subsequence at position 197 - 197 aligns to "S" in entry P49017 (individually applies "S-adenosyl-L-methionine")

... then these annotations are applied i

Protein namesi

  • Recommended name:
    Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE (EC:2.1.1.163, EC:2.1.1.201)
    Alternative name(s):
    2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
    Demethylmenaquinone methyltransferase
  • Recommended name:
    Demethylmenaquinone methyltransferase (EC:2.1.1.163)

Gene namesi

  • Name:ubiE
  • Name:menG

Functioni

  • Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
  • Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

Pathwayi

  • Pathwayi: ubiquinone biosynthesis

    This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.
  • Pathwayi: menaquinone biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate. This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sequence similaritiesi

Catalytic activityi

  • A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.
  • S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
  • A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.

Regioni

  • S-adenosyl-L-methionine binding (to residues corresponding to positions 179 - 180)

Binding sitei

  • S-adenosyl-L-methionine (to residues corresponding to position 122)
  • S-adenosyl-L-methionine (to residues corresponding to position 148)
  • S-adenosyl-L-methionine (to residues corresponding to position 197)

Keywordsi

GO (Gene Ontology) termsi

  • GO:0009234 menaquinone biosynthetic process
  • GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
  • GO:0009060 aerobic respiration

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