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If a protein meets these conditions... i

Common conditions

Special conditions

... then these annotations are applied i

Protein namei

  • Recommended name:
    Kynureninase (EC:3.7.1.3)

Catalytic activityi

  • L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.
  • L-kynurenine + H2O = anthranilate + L-alanine.

Functioni

  • Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.

Subcellular locationi

Cofactori

Sequence similaritiesi

Pathwayi

  • Pathwayi: L-kynurenine degradation

    This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine. This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.
  • Pathwayi: NAD(+) biosynthesis

    This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine. This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Subunit structurei

  • Homodimer.

Keywordsi