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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 145 - 145 aligns to "C" in entry Q97F65 Subsequence at position 148 - 148 aligns to "C" in entry Q97F65 Subsequence at position 183 - 183 aligns to "C" in entry Q97F65 Subsequence at position 186 - 186 aligns to "[CH]" in entry Q97F65
    • Subsequence at position 15 - 22 aligns to "[GSA]-x(4)-G-K-[ST]" in entry Q97F65 (individually applies "ATP")
    • Subsequence at position 88 - 91 aligns to "[DE]-E-x-[QHN]" in entry Q97F65 (individually applies "ATP")
    • Subsequence at position 89 - 89 aligns to "E" in entry Q97F65 (individually applies "Proton acceptor")
  • Subsequence at position 145 - 145 aligns to "C" in entry Q97F65 (applies "Zinc") Subsequence at position 148 - 148 aligns to "C" in entry Q97F65 (applies "Zinc") Subsequence at position 183 - 183 aligns to "C" in entry Q97F65 (applies "Zinc") Subsequence at position 186 - 186 aligns to "[CH]" in entry Q97F65 (applies "Zinc")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Thymidine kinase (EC:2.7.1.21)

Gene namei

  • Name:tdk

Subunit structurei

  • Homotetramer.

Subcellular locationi

Sequence similaritiesi

Catalytic activityi

  • ATP + thymidine = ADP + thymidine 5'-phosphate.

Active sitei

  • Proton acceptor (to residues corresponding to position 89)

Metal bindingi

  • Zinc (to residues corresponding to position 145)
  • Zinc (to residues corresponding to position 148)
  • Zinc (to residues corresponding to position 183)
  • Zinc (to residues corresponding to position 186)

Nucleotide bindingi

  • ATP (to residues corresponding to positions 15 - 22)
  • ATP (to residues corresponding to positions 88 - 91)

Keywordsi

GO (Gene Ontology) termsi