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If a protein meets these conditions... i

Common conditions

Special conditions

    • Subsequence at position 40 - 47 aligns to "M-x(3)-H-x(2)-H" in entry P9WIL5 (individually applies "ATP")
    • Subsequence at position 47 - 47 aligns to "H" in entry P9WIL5 (individually applies "Proton donor")
    • Subsequence at position 72 - 72 aligns to "Q" in entry P9WIL5 (individually applies "Beta-alanine")
    • Subsequence at position 72 - 72 aligns to "Q" in entry P9WIL5 (individually applies "Pantoate")
    • Subsequence at position 158 - 161 aligns to "G-x(2)-D" in entry P9WIL5 (individually applies "ATP")
    • Subsequence at position 164 - 164 aligns to "Q" in entry P9WIL5 (individually applies "Pantoate")
    • Subsequence at position 187 - 187 aligns to "[VLIGA]" in entry P9WIL5 (individually applies "ATP; via amide nitrogen and carbonyl oxygen")
    • Subsequence at position 195 - 198 aligns to "x(3)-R" in entry P9WIL5 (individually applies "ATP")

... then these annotations are applied i

Protein namei

  • Recommended name:
    Pantothenate synthetase (EC:6.3.2.1)
    Short name:
    PS
    Alternative name(s):
    Pantoate-activating enzyme
    Pantoate--beta-alanine ligase

Gene namei

  • Name:panC

Sequence similaritiesi

Catalytic activityi

  • ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

Miscellaneousi

  • The reaction proceeds by a bi uni uni bi ping pong mechanism.

Functioni

  • Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Subunit structurei

  • Homodimer.

Pathwayi

  • Pathwayi: (R)-pantothenate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine. This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.